Neurotransmitters and Drugs
Zygmunt L Kruk (Author), Christopher J Pycock (Author)
This book is intended for students of medicine, pharmacy and other biological disciplines, who want to have a working knowledge of the mechanisms of action, uses and adverse effects of drugs which modify the activity of neurotransmitters in the peripheral and central nervous systems. It is suitable for undergraduates and for post-graduates on taught higher degree courses and diplomas. New information and concepts have been incorporated into the text as appropriate, and references have been updated. Excitatoryand inhibitory amino acids are considered in two chapters, and the last chapter of the first two editions (which considered drugs which do not interact selectively with neurotransmitters) has been subsumed into other sections. The third edition follows the tried format of previous editions. Following a chapter which introduces the biology and pharmacology of neurotransmission, subsequent chapters deal with synthesis, storage, release, receptors and inactivation of individual neurotransmitters, together with a consideration of therapeutic uses and mechanisms of adverse effects
eBook, English, 1991
Third edition View all formats and editions
Springer Netherlands : Imprint : Springer, Dordrecht, 1991
1 online resource (IX, 204 pages)
9789401131346, 9401131341
1058112350
Available in another form:
1 Neurotransmission: Sites at which drugs modify neurotransmission
1.1 The neurone
1.2 Axonal transport
1.3 Neuronal cell membranes
1.4 Precursors
1.5 Synthesis
1.6 Storage
1.7 Organelles and enzymes
1.8 Release
1.9 Receptors
1.10 Inactivation
1.11 Neurotransmitters or neuromodulators
1.12 Neurotransmitters in the nervous system
1.13 Neurotransmitters and drugs
Further reading
2 Acetylcholine
2.1 Synthesis
2.2 Storage
2.3 Release
2.4 Cholinergic receptors
2.5 Inactivation of acetylcholine
2.6 Therapeutic applications and consequences of drugs acting at cholinergic synapses
Further reading
3 Noradrenaline
3.1 Synthesis
3.2 Storage
3.3 Release
3.4 Adrenoreceptors
3.5 Inactivation of noradrenaline
3.6 Therapeutic applications and consequences of drugs acting at noradrenergic synapses
Further reading
4 Dopamine
4.1 Synthesis
4.2 Storage
4.3 Release
4.4 Dopamine systems
4.5 Inactivation of dopamine
4.6 Therapeutic applications and consequences of drugs acting at dopaminergic synapses
Further reading
5 5-Hydroxytryptamine
5.1 Synthesis
5.2 Storage
5.3 Release
5.4 5-HT receptors
5.5 Inactivation of 5-HT
5.6 Therapeutic applications and consequences of drugs acting at 5-HT synapses
Further reading
6 Histamine
6.1 Synthesis
6.2 Storage
6.3 Release
6.4 Histamine receptors
6.5 Inactivation of histamine
6.6 Therapeutic applications and consequences of drug action on histamine systems
Further reading
7 Inhibitory amino acids: GABA, glycine and taurine
7.1 Amino acids as neurotransmitters
7.2?-aminobutyric acid
7.3 Glycine
7.4 Taurine
Further reading
8 Excitory amino acids: L-glutamic acid and L-aspartic acid
8.1 Synthesis
8.2 Storage
8.3 Release
8.4 Excitatory amino acid receptors in the CNS
8.5 Inactivation of released excitory amino acids
8.6 Functional roles of cerebral excitory amino acid neurotransmitters
Further reading
9 Peptides and neuronal function
9.1 Peptides as neurotransmitters and hormones
9.2 Synthesis, storage, transport, release and inactivation of neuropeptides
9.3 Co-existence and co-transmission of peptides with classical neurotransmitters
9.4 Opioid peptides
9.5 Substance P (the tachykinins)
9.6 Cholecystokinin (CCK)
9.7 Vasoactive intestinal polypeptide
9.8 Neurotensin
9.9 Somatostatin
9.10 Bombesin
Further reading